ALBUMIN FUSION TECHNOLOGY EXTENDS FACTOR IX TIME IN CIRCULATION
Albumin is a naturally occurring protein that was specifically selected for its prolonged half‑life
Recombinant albumin IDELVION is formed by fusing recombinant albumin, known for its long half-life and low risk for immunogenic reaction, with recombinant Factor IX (rFIX).
Cleavable peptide linker Upon initiation of the coagulation cascade, recombinant albumin is cleaved, only releasing activated Factor IX when needed for coagulation.
rFIX The rFIX remains linked to the recombinant albumin via a cleavable peptide linker so it remains inactive until it’s needed to control a bleed.
-
1
Recombinant albumin IDELVION is formed by fusing recombinant albumin, known for its long half-life and low risk for immunogenic reaction, with recombinant Factor IX (rFIX).
-
2
Cleavable peptide linker Upon initiation of the coagulation cascade, recombinant albumin is cleaved, only releasing activated Factor IX (FIX) when needed for coagulation.
-
3
rFIX The rFIX remains linked to the recombinant albumin via a cleavable peptide linker so it remains inactive until it’s needed to control a bleed.
*The median AsBR for patients who started and stayed on 7- or 14-day prophylaxis was 0. For patients who switched to prophylaxis from on-demand, the median AsBR was 0.7.