IDELVION USES ALBUMIN FUSION TECHNOLOGY TO EXTEND FACTOR IX TIME IN CIRCULATION
Albumin is a naturally occurring protein that was specifically selected for its prolonged half-life
IDELVION is formed by fusing recombinant albumin, known for its long half-life and low risk for immunogenic reaction, with recombinant Factor IX (rFIX).
The rFIX remains linked to the recombinant albumin via a cleavable peptide linker so it remains inactive until it's needed to control a bleed.
Cleavable Peptide Linker
Upon initiation of the coagulation cascade, recombinant albumin is cleaved, releasing only activated Factor IX (FIX) when needed for coagulation.