IDELVION USES ALBUMIN FUSION TECHNOLOGY TO EXTEND FACTOR IX TIME IN CIRCULATION

Albumin is a naturally occurring protein that was specifically selected for its prolonged half-life

Recombinant IX fusion protein
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Recombinant Albumin

IDELVION is formed by fusing recombinant albumin, known for its long half-life and low risk for immunogenic reaction, with recombinant Factor IX (rFIX).

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rFIX

The rFIX remains linked to the recombinant albumin via a cleavable peptide linker so it remains inactive until it's needed to control a bleed.

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Cleavable Peptide Linker

Upon initiation of the coagulation cascade, recombinant albumin is cleaved, releasing only activated Factor IX (FIX) when needed for coagulation.

ZERO median annualized spontaneous bleeds when IDELVION was used prophylactically in clinical trials

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