Choose the regimen that’s right for your patients and adjust based on their clinical condition and response.
*In patients 12 years and older on a weekly dose of ≤40 IU/kg for 1 month while not requiring dose adjustments or experiencing spontaneous bleeding.
Type of Bleeding Episode | Circulating Factor IX Activity Required (% or IU/dL) | Frequency of Dosing (hours) | Duration of Therapy (days)† |
---|---|---|---|
MINOR OR MODERATE Uncomplicated hemarthrosis, muscle bleeding (except iliopsoas) or oral bleeding | 30–60 | 48–72 | At least 1 day, until bleeding stops and healing is achieved. Single dose should be sufficient for majority of bleeds. |
MAJOR Life or limb threatening hemorrhage, deep muscle bleeding, including iliopsoas, intracranial, retropharyngeal | 60–100 | 48–72 | 7–14 days, until bleeding stops and healing is achieved. Maintenance dose weekly. |
Type of Bleeding Episode | |
MINOR OR MODERATE Uncomplicated hemarthrosis, muscle bleeding (except iliopsoas) or oral bleeding | MAJOR Life or limb threatening hemorrhage, deep muscle bleeding, including iliopsoas, intracranial, retropharyngeal |
Circulating Factor IX Activity Required (% or IU/dL) | |
30–60 | 60–100 |
Frequency of Dosing (hours) | |
48–72 | 48–72 |
Duration of Therapy (days)† | |
At least 1 day, until bleeding stops and healing is achieved. Single dose should be sufficient for majority of bleeds. | 7–14 days, until bleeding stops and healing is achieved. Maintenance dose weekly. |
Type of Surgery | Circulating Factor IX Activity Required (% or IU/dL) | Frequency of Dosing (hours) | Duration of Therapy (days)† |
---|---|---|---|
MINOR (including uncomplicated tooth extraction) | 50–80 | 48–72 | At least 1 day, or until healing is achieved. Single dose should be sufficient for a majority of minor surgeries. |
MAJOR (including intracranial, pharyngeal, retropharyngeal, retroperitoneal) | 60–100 (initial level) |
48–72 | 7–14 days, or until bleeding stops and healing is achieved. Repeat dose every 48–72 hours for the first week or until healing is achieved. Maintenance dose 1–2 times per week. |
Type of Surgery | |
MINOR (including uncomplicated tooth extraction) | MAJOR (including intracranial, pharyngeal, retropharyngeal, retroperitoneal) |
Circulating Factor IX Activity Required (% or IU/dL) | |
50–80 | 60–100 (initial level) |
Frequency of Dosing (hours) | |
48–72 | 48–72 |
Duration of Therapy (days)† | |
At least 1 day, or until healing is achieved. Single dose should be sufficient for a majority of minor surgeries. | 7–14 days, or until bleeding stops and healing is achieved. Repeat dose every 48–72 hours for the first week or until healing is achieved. Maintenance dose 1–2 times per week. |
†Adapted from the WFH Guidelines for the Management of Hemophilia.
5 vial sizes for optimal flexibility and efficiency
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KIT NDC: 69911-864-02 2.5-mL diluent
KIT NDC: 69911-865-02 2.5-mL diluent
KIT NDC: 69911-866-02 2.5-mL diluent
KIT NDC: 69911-867-02 5-mL diluent
KIT NDC: 69911-869-02 5-mL diluent
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“Extending dosing let me work with my doctor to develop a dosing schedule that works for me.”
Watch Ray’s full story
Patients who started and stayed on prophylaxis prove IDELVION has powerful efficacy with both 7- and 14-day dosing‡
‡Of the 23 subjects in Arm 2, 19 were transitioned from on-demand to 7-day prophylaxis. The median AsBR during prophylaxis treatment was 0.7 (range: 0 to 4.2). Data for Arms 1 and 2 based on matched-pairs design.
References: 1. Gill JC, Roberts J, Li Y, Castaman G. Sustained high trough factor IX activity levels with continued use of rIX-FP in adult and paediatric patients with haemophilia B. Haemophilia. 2019. doi:10.1111/hae.13735. 2. Santagostino E, Martinowitz U, Lissitchkov T, et al. Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial. Blood. 2016;127(14):1761-1769. doi:10.1182/blood-2015-09-669234.